Patient-Specific Pharmacogenomics demonstrates xCT as Predictive Therapeutic Target in Colon Cancer with Possible Implications in Tumor Connectivity
RNA-seq (gene expression) · human · 73 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 73 samples: 64 distinct titles, 7 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Patient-specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivityMolecular oncology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305337_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1305329 and SRA study SRP608769. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 73 sample titles: 64 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9168882 Healthy colon cells, Patient A sample 1
- GSM9168883 Healthy colon cells, Patient A sample 2
- GSM9168884 Tumor colon cells, Patient A sample 1
- GSM9168885 Tumor colon cells, Patient A sample 2
- GSM9168886 Healthy colon cells, Patient B
- GSM9168887 Tumor colon cells, Patient B
- GSM9168888 Tumor colon cells, Patient C
- GSM9168889 Healthy colon cells, Patient C
- GSM9168890 Tumor colon cells, Patient D
- GSM9168891 Healthy colon cells, Patient D
- GSM9168892 Tumor colon cells, Patient E
- GSM9168893 Healthy colon cells, Patient E
- GSM9168894 Tumor colon cells, Patient F
- GSM9168895 Healthy colon cells, Patient F
- GSM9168896 Tumor colon cells, Patient G
- GSM9168897 Healthy colon cells, Patient G
- GSM9168898 Tumor colon cells, Patient H
- GSM9168899 Healthy colon cells, Patient H
- GSM9168900 Tumor colon cells, Patient I
- GSM9168901 Healthy colon cells, Patient I
- GSM9168902 Tumor colon cells, Patient J
- GSM9168903 Healthy colon cells, Patient J
- GSM9168904 Tumor colon cells, Patient K
- GSM9168905 Healthy colon cells, Patient K
- GSM9168906 Tumor colon cells, Patient L
- GSM9168907 Healthy colon cells, Patient L
- GSM9168908 Tumor colon cells, Patient M
- GSM9168909 Healthy colon cells, Patient M
- GSM9168910 Tumor colon cells, Patient N
- GSM9168911 Healthy colon cells, Patient N
- GSM9168912 Tumor colon cells, Patient O
- GSM9168913 Healthy colon cells, Patient O
- GSM9168914 Tumor colon cells, Patient P
- GSM9168915 Healthy colon cells, Patient P
- GSM9168916 Tumor colon cells, Patient Q
- GSM9168917 Healthy colon cells, Patient Q
- GSM9168918 Tumor colon cells, Patient R
- GSM9168919 Healthy colon cells, Patient R
- GSM9168920 Tumor colon cells, Patient S
- GSM9168921 Healthy colon cells, Patient S
+ 33 more — browse all 73 samples with per-sample file links →
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE273036 Multi-Omics Analysis and Molecular Subtypes Provide Potential Therapeutic Implications in Fumarate Hydratase-deficient Renal Cell Carcinoma 93 samples shares implications, therapeutic
- GSE314036 Oncolytic vaccinia virus JX-594 demonstrates subtype-specific efficacy and predictive biomarkers in gastric cancer cell lines 49 samples shares demonstrates, predictive
- GSE290805 Meningioma microenvironment harbors a rich immune landscape with therapeutic implications (Bulk RNA-seq part) 47 samples shares implications, therapeutic
- GSE250236 Heterogeneous expression of cell surface markers in human myeloma cell lines: implications for disease modelling and therapeutic targeting 18 samples shares implications, therapeutic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.