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RNA-seq profiling of A375 melanoma cells treated with Salvianolic Acid B

GSE305377 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/09/29 Platform GPL16791
Summary
This dataset describes the transcriptomic profiling of A375 human melanoma cells treated with Salvianolic Acid B (Sal B), a bioactive compound derived from Salvia miltiorrhiza. A375 cells were cultured under standard conditions and treated with Sal B at concentrations of 100 µM and 200 µM for 48 hours, with an untreated control group included for comparison. Total RNA was extracted from each group and subjected to RNA-seq analysis to investigate global gene expression changes induced by Sal B. The goal of this study was to identify differentially expressed genes and pathways related to glycolysis inhibition and immune modulation, providing insight into the potential anti-tumor mechanisms of Sal B in melanoma. This dataset may serve as a resource for exploring the metabolic and immunological effects of Salvianolic Acid B in melanoma cells.
Published in
Salvianolic acid B inhibits melanoma via dual modulation of glycolysis and NK/T cell immunity
Zhang Y, Li C, Chen J · International immunopharmacology 2025 · PMID 40987026 · doi:10.1016/j.intimp.2025.115567
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Direct links to NCBI, no account and no request form: the whole study as GSE305377_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1305429 and SRA study SRP608696. Searching any of these in the dataset finder brings you back here.

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