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GPR35+ tumor-associated neutrophils promote tumor growth in hepatocellular carcinoma.

GSE305407 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/05 Platform GPL24247
Summary
Bulk RNA-seq profiling of tumor-associated neutrophils from Hepa1-6 mouse hepatocellular carcinoma (HCC) models. Neutrophils were isolated from mice HCC tissues and classified as GPR35+ or GPR35- subsets (n=3 per group). Differential expression analysis revealed significant upregulation of MAPK signaling pathway and pathways associated with neutrophil migration and cytokines production in GPR35+ neutrophils. These data support the pro-tumorigenic role of GPR35+ neutrophils in HCC.
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Direct links to NCBI, no account and no request form: the whole study as GSE305407_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1305477 and SRA study SRP608748. Searching any of these in the dataset finder brings you back here.

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