GEO series
Radiosensitizing effect of THBS1 knockdown in radioresistant head and neck carcinoma cell lines
GSE305473
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/08/21
GPL24676
Summary
This study aimed to investigate the radiosensitizing effects of THBS1 knockdown in radioresistant head and neck squamous cell carcinoma (HNSCC) cell lines. Using siRNA-mediated silencing of THBS1 in CAL27 and Detroit 562 cells, we examined transcriptomic changes associated with enhanced sensitivity to proton beam irradiation. Bulk RNA-seq was performed to profile genome-wide expression patterns in control and THBS1-depleted cells, providing insights into gene expression programs linked to THBS1-mediated radioresistance and potential therapeutic targets.
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