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TIMP1-Mediated M2 Macrophage Polarization Facilitates Liver Metastasis in Colorectal Cancer

GSE305642 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/14 Platform GPL24247
Summary
Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality globally, with liver metastasis (CRLM) accounting for the majority of CRC-associated deaths. Although advances in early detection and treatment have improved outcomes, the prognosis for patients with advanced disease remains dismal. Recent studies have underscored the critical role of the hepatic pre-metastatic niche (PMN) in facilitating CRC dissemination, where M2-polarized macrophages play a central role in promoting immune suppression and metastatic colonization. However, the molecular mechanisms driving M2 polarization in this context remain incompletely understood.
Published in
Integrin-Mediated TIMP1 Signaling Reprograms Liver Macrophages and Accelerates Colorectal Cancer Metastasis
Liu J, Zhao L, Wang L et al. · Cells 2025 · PMID 41511313 · doi:10.3390/cells15010029
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Also filed as BioProject PRJNA1307398 and SRA study SRP610318. Searching any of these in the dataset finder brings you back here.

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