← BioTransfer GEO Dataset Finder
GEO series

Transcriptomic data of inhibition of CDK12 in GBM12 cell line by SR-4835 treatment

GSE306109 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/29 Platform GPL34295
Summary
This dataset contains transcriptomic profiles of the human glioblastoma cell line GBM12 following treatment with SR-4835, a selective CDK12 inhibitor. GBM12 cells were treated with SR-4835 or vehicle control for 24 hours, and total RNA was extracted for RNA sequencing. The study aims to elucidate transcriptional changes associated with CDK12 inhibition in glioblastoma and to identify downstream targets or pathways affected by SR-4835.
Published in
CDK12 regulates cellular metabolism to promote glioblastoma growth
Mun JY, Shu C, Gao Q et al. · JCI insight 2025 · PMID 40996961 · doi:10.1172/jci.insight.190780
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE306109_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1309139 and SRA study SRP610523. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.