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Long FAM13A isoforms regulate human lung epithelial development in vitro

GSE306210 Homo sapiens Expression profiling by high throughput sequencing; Other 6 samples Submitted 2026/07/15 Platform GPL18573
Summary
We performed single cell transcriptomic profiling of induced human pluripotent stem cells (iPSCs)-derived anterior foregut progenitors (D6) and lung progenitors (D15). FAM13A-long isoforms were knocked out of iPSCs prior to differentiation. Prior to capture, cells were labelled with hashing antibodies (HTO). Cells were captured for 10x Genomics Single cell capture (V3 protocol), and GEX and HTO libraries were sequenced. HTODemux function was used to demultiplex the samples. FAM13A-long KO changed clustering of D15 NKX2-1+ lung progenitors
Published in
Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development
Werder RB, Homps-Legrand M, Hyatt R et al. · American journal of respiratory cell and molecular biology 2026 · PMID 42083809 · doi:10.1093/ajrcmb/aanag078
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Also filed as BioProject PRJNA1309688 and SRA study SRP610895. Searching any of these in the dataset finder brings you back here.

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