Disparate Leukemia Mutations Converge on Nuclear Phase-Separated Condensates
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × NTC_DMSO vs 3 × dTAG_Cbodynull vs 3 × dTAG_FL-NPM1c vs 3 × dTAG_mCherryGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Disparate leukemia mutations converge on nuclear phase-separated condensatesCell · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306285_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1310414 and SRA study SRP612465. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9196804 NTC_DMSO_001 NTC_DMSO
- GSM9196805 NTC_DMSO_002 NTC_DMSO
- GSM9196806 NTC_DMSO_003 NTC_DMSO
- GSM9196807 dTAG_Cbodynull_001 dTAG_Cbodynull
- GSM9196808 dTAG_Cbodynull_002 dTAG_Cbodynull
- GSM9196809 dTAG_Cbodynull_003 dTAG_Cbodynull
- GSM9196810 dTAG_FL-NPM1c_001 dTAG_FL-NPM1c
- GSM9196811 dTAG_FL-NPM1c_002 dTAG_FL-NPM1c
- GSM9196812 dTAG_FL-NPM1c_003 dTAG_FL-NPM1c
- GSM9196813 dTAG_mCherry_001 dTAG_mCherry
- GSM9196814 dTAG_mCherry_002 dTAG_mCherry
- GSM9196815 dTAG_mCherry_003 dTAG_mCherry
- GSE285077 Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles [RNA-seq] 76 samples shares condensates, nuclear
- GSE287297 Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia [RNA-seq] 70 samples shares mutations, leukemia
- GSE304350 Distinct and convergent effects of SF3B1 mutations in human breast cancer 30 samples shares mutations, converge
- GSE268355 Cancer-associated SF3B1 Mutations Inhibit mRNA Nuclear Export by Disrupting SF3B1–THOC5 Interactions 12 samples shares mutations, nuclear
- GSE268035 STAG2 Mutations Reshape the Cohesin-Structured Spatial Chromatin Architecture to Drive Gene Regulation in Acute myeloid Leukemia 541 samples shares mutations, leukemia
- GSE314941 Cohesin mutations suppress HLA class II gene expression to promote immune evasion during the progression to acute leukemia in children with Down syndrome 180 samples shares mutations, leukemia
- GSE234558 Tracking rare single donor and recipient immune and leukemia cells after allogeneic hematopoietic cell transplantation using mitochondrial DNA mutations 85 samples shares mutations, leukemia
- GSE314930 Cohesin mutations suppress HLA class II gene expression to promote immune evasion during the progression to acute leukemia in children with Down syndrome [CUT&Run] 72 samples shares mutations, leukemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.