RNA-seq of a Leigh Syndrome patient blood being treated with Omaveloxolone
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306316_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1310465 and SRA study SRP612382. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9197262 Pre-treated blood, replicate 1 Pre-treated blood,
- GSM9197263 Pre-treated blood, replicate 2 Pre-treated blood,
- GSM9197264 Pre-treated blood, replicate 3 Pre-treated blood,
- GSM9197265 Blood from patient 1 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 1 Blood from patient 1 mo…
- GSM9197266 Blood from patient 1 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 2 Blood from patient 1 mo…
- GSM9197267 Blood from patient 1 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 3 Blood from patient 1 mo…
- GSM9197268 Blood from patient 2 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 1 Blood from patient 2 mo…
- GSM9197269 Blood from patient 2 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 2 Blood from patient 2 mo…
- GSM9197270 Blood from patient 2 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 3 Blood from patient 2 mo…
- GSM9197271 Blood from patient 4 month post-treatment with Omaveloxolone at a dose of 50 mg PO daily, replicate 1 Blood from patient 4 mo…
- GSM9197272 Blood from patient 4 month post-treatment with Omaveloxolone at a dose of 50 mg PO daily, replicate 2 Blood from patient 4 mo…
- GSM9197273 Blood from patient 4 month post-treatment with Omaveloxolone at a dose of 50 mg PO daily, replicate 3 Blood from patient 4 mo…
- GSM9197274 Blood from patient 5 month post-treatment with Omaveloxolone at a dose of 50 mg PO daily, replicate 1 Blood from patient 5 mo…
- GSM9197275 Blood from patient 5 month post-treatment with Omaveloxolone at a dose of 50 mg PO daily, replicate 2 Blood from patient 5 mo…
- GSM9197276 Blood from patient 5 month post-treatment with Omaveloxolone at a dose of 50 mg PO daily, replicate 3 Blood from patient 5 mo…
- GSM9197277 Blood from patient 7 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 1 Blood from patient 7 mo…
- GSM9197278 Blood from patient 7 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 2 Blood from patient 7 mo…
- GSM9197279 Blood from patient 7 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 3 Blood from patient 7 mo…
- GSM9197280 Blood from patient 9 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 1 Blood from patient 9 mo…
- GSM9197281 Blood from patient 9 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 2 Blood from patient 9 mo…
- GSM9197282 Blood from patient 9 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 3 Blood from patient 9 mo…
- GSM9197283 Blood from patient 10 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 1 Blood from patient 10 m…
- GSM9197284 Blood from patient 10 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 2 Blood from patient 10 m…
- GSM9197285 Blood from patient 10 month post-treatment with Omaveloxolone at a dose of 100 mg PO daily, replicate 3 Blood from patient 10 m…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.