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Based on single-cell sequencing analysis of CD4+ T cells and B cells in patients with lupus nephritis, the heterogeneity of these cells was investigated.

GSE306378 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/01 Platform GPL24676
Summary
Utilizing single-cell technology to analyze the heterogeneity of CD4+ T cells and B cells in patients with lupus nephritis.We have delineated the immune cell profile of PBMC in LN patients, and focused on describing the heterogeneity characteristics of CD4+ T cells and B cells. Some specific cell subtypes and ligand-receptor pairs were identified, which indicate potential therapeutic targets for lupus erythematosus.
Published in
Single-cell sequencing-based analysis of CD4 + T-cell and B-cell heterogeneity in patients with lupus nephritis
Cheng LL, Tang ZF, Li M et al. · BMC medical genomics 2026 · PMID 41540405 · doi:10.1186/s12920-025-02277-3
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Also filed as BioProject PRJNA1310548 and SRA study SRP612291. Searching any of these in the dataset finder brings you back here.

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