Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy
RNA-seq (gene expression) · human · 76 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 76 samples: 76 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapyJCI insight · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306517_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1311026 and SRA study SRP612710. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 76 sample titles: 76 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9202541 Patient 0001, 2 Years
- GSM9202542 Patient 0001, 6 Months
- GSM9202543 Patient 0001, Baseline
- GSM9202544 Patient 0002, 2 Years
- GSM9202545 Patient 0002, 6 Months
- GSM9202546 Patient 0002, Baseline
- GSM9202547 Patient 0003, 2 Years
- GSM9202548 Patient 0004, Baseline
- GSM9202549 Patient 0005, 2 Years
- GSM9202550 Patient 0005, 6 Months
- GSM9202551 Patient 0005, Baseline
- GSM9202552 Patient 0007, 2 Years
- GSM9202553 Patient 0007, Baseline
- GSM9202554 Patient 0008, 2 Years
- GSM9202555 Patient 0008, 6 Months
- GSM9202556 Patient 0008, Baseline
- GSM9202557 Patient 0009, 2 Years
- GSM9202558 Patient 0009, 6 Months
- GSM9202559 Patient 0009, Baseline
- GSM9202560 Patient 0010, 2 Years
- GSM9202561 Patient 0010, 6 Months
- GSM9202562 Patient 0010, Baseline
- GSM9202563 Patient 0011, 2 Years
- GSM9202564 Patient 0011, 6 Months
- GSM9202565 Patient 0011, Baseline
- GSM9202566 Patient 0012, 2 Years
- GSM9202567 Patient 0012, 6 Months
- GSM9202568 Patient 0012, Baseline
- GSM9202569 Patient 0013, 2 Years
- GSM9202570 Patient 0013, 6 Months
- GSM9202571 Patient 0013, Baseline
- GSM9202572 Patient 0014, 2 Years
- GSM9202573 Patient 0014, 6 Months
- GSM9202574 Patient 0014, Baseline
- GSM9202575 Patient 0015, 6 Months
- GSM9202576 Patient 0015, Baseline
- GSM9202577 Patient 0015, 2 Years
- GSM9202578 Patient 0016, 2 Years
- GSM9202579 Patient 0016, 6 Months
- GSM9202580 Patient 0016, Baseline
+ 36 more — browse all 76 samples with per-sample file links →
- GSE311629 Biomimetic model of human small airways reveals functional impacts of the cystic fibrosis microenvironment on monocytes and macrophages 35 samples shares fibrosis, cystic, airway
- GSE285099 RNA sequencing of human airway epithelial cultures from cystic fibrosis (CF) and non-CF donors exposed to tumor necrosis factor-alpha and interleukin-17 (TNFα+IL-17) for 5 hours 24 samples shares fibrosis, cystic, airway
- GSE271359 Identifying modulators of inflammation in an in vitro airway epithelial inflammation model using an arrayed CRISPRi screen 186 samples shares modulator, airway
- GSE302095 Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium 132 samples shares epithelium, airway
- GSE325885 Polymicrobial extracellular vesicles reduce the innate immune response of human cystic fibrosis bronchial epithelial cells 28 samples shares fibrosis, cystic
- GSE272860 Hypoxia promotes airway differentiation in the human lung epithelium [Bulk RNA-seq] 18 samples shares epithelium, airway
- GSE275264 Single cell Transcriptomes Reveals Aberrant Airway cell-cell interations in Pulmonary Fibrosis 16 samples shares fibrosis, airway
- GSE309705 Transcriptomic Profiling of Bronchial Epithelium Reveals Dysregulated Interferon and Inflammatory Responses to Rhinovirus in Exacerbation-Prone Pediatric Asthma 274 samples shares epithelium
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.