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Deciphering the role of tumor cell-intrinsic Sema4D in TNBC mouse tumor using single-cell RNA sequencing

GSE306581 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/31 Platform GPL28330
Summary
Sema4D (Semaphorin 4D, also known as CD100) is a member of the class IV semaphorin family and is predominantly expressed on the surface of lymphocytes, monocytes, macrophages, and endothelial cells. The current understanding of Sema4D function is focused on its receptor-mediated signaling activities with limited data on its intrinsic mechanisms. However, the immunological roles and functional mechanism of tumor cell-intrinsic Sema4D regulating immune escape remain largely unknown. This study employs single-cell RNA sequencing (scRNA-seq) to investigate cellular and regulatory role of Sema4d in TNBC mouse tumors.
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Direct links to NCBI, no account and no request form: the whole study as GSE306581_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1311343 and SRA study SRP613438. Searching any of these in the dataset finder brings you back here.

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