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Sensitive CAR T cells redefine targetable CD70 expression in solid tumors [CITE-seq]

GSE306608 Homo sapiens Expression profiling by high throughput sequencing; Other 6 samples Submitted 2026/02/26 Platform GPL34284
Summary
Overcoming tumor antigen heterogeneity in solid tumors is a major challenge for cancer immunotherapies including chimeric antigen receptor (CAR) T cells. Unlike CD19 for B-cell malignancies, no target with pan-cellular expression in solid tumors and absence in normal vital cells has been identified. CD70 is a potential candidate, confined to immune cell subsets and aberrantly expressed in many solid tumors, albeit heterogeneously. We find that CD70 expression in heterogeneous tumors is not binary but ranges from high to very low, appearing negative. We show that CD70-heterogeneous tumors are efficiently eliminated by highly sensitive CD70 receptors where prototypic CAR T cells fail. We further identify an epigenetic signature that predicts targetable expression. These findings provide a potential strategy to treat a broad range of solid tumors.
Published in
Sensitive CAR T cells redefine targetable CD70 expression in solid tumors
Hanina SA, Park T, Lopez M et al. · Science (New York, N.Y.) 2026 · PMID 41747043 · doi:10.1126/science.adv7378
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Also filed as BioProject PRJNA1311465 and SRA study SRP613505. Searching any of these in the dataset finder brings you back here.

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