QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5’splice sites
RNA-seq (gene expression) · human · 60 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 60 samples: 22 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5' splice sitesbioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306691_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1311820 and SRA study SRP613447. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 60 samples.
How we read this: 22 replicated groups read from 60 sample titles; they account for 60 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9204030 QKI_D0_IP1 QKI_D0_IP
- GSM9204031 QKI_D0_IP2 QKI_D0_IP
- GSM9204032 QKI_D0_IP3 QKI_D0_IP
- GSM9204033 QKI_D0_input1 QKI_D0_input
- GSM9204034 QKI_D0_input2 QKI_D0_input
- GSM9204035 QKI_D0_input3 QKI_D0_input
- GSM9204036 QKI_D4_IP1 QKI_D4_IP
- GSM9204037 QKI_D4_IP2 QKI_D4_IP
- GSM9204038 QKI_D4_IP3 QKI_D4_IP
- GSM9204039 QKI_D4_input1 QKI_D4_input
- GSM9204040 QKI_D4_input2 QKI_D4_input
- GSM9204041 QKI_D4_input3 QKI_D4_input
- GSM9204042 QKI_D8_IP1 QKI_D8_IP
- GSM9204043 QKI_D8_IP2 QKI_D8_IP
- GSM9204044 QKI_D8_IP3 QKI_D8_IP
- GSM9204045 QKI_D8_input1 QKI_D8_input
- GSM9204046 QKI_D8_input2 QKI_D8_input
- GSM9204047 QKI_D8_input3 QKI_D8_input
- GSM9206220 QKI_MYC_WT_IP1 QKI_MYC_WT_IP
- GSM9206221 QKI_MYC_WT_IN1 QKI_MYC_WT_IN
- GSM9206222 QKI_MYC_WT_IP2 QKI_MYC_WT_IP
- GSM9206223 QKI_MYC_WT_IN2 QKI_MYC_WT_IN
- GSM9206224 QKI_MYC_MUT_IP1 QKI_MYC_MUT_IP
- GSM9206225 QKI_MYC_MUT_IN1 QKI_MYC_MUT_IN
- GSM9206226 QKI_MYC_MUT_IP2 QKI_MYC_MUT_IP
- GSM9206227 QKI_MYC_MUT_IN2 QKI_MYC_MUT_IN
- GSM9206228 QKI_293T_input1 QKI_293T_input
- GSM9206229 QKI_293T_IP1 QKI_293T_IP
- GSM9206230 QKI_293T_input2 QKI_293T_input
- GSM9206231 QKI_293T_IP2 QKI_293T_IP
- GSM9206261 D4-WT-1 D4-WT
- GSM9206262 D4-WT-2 D4-WT
- GSM9206263 D4-WT-3 D4-WT
- GSM9206264 D4-KO-1 D4-KO
- GSM9206265 D4-KO-2 D4-KO
- GSM9206266 D4-KO-3 D4-KO
- GSM9206267 D8-WT-2 D8-WT
- GSM9206268 D8-WT-3 D8-WT
- GSM9206269 D8-WT-4 D8-WT
- GSM9206270 D8-KO-1 D8-KO
+ 20 more — browse all 60 samples with per-sample file links →
- GSE306690 QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5’splice sites [RNA-Seq] 30 samples shares qki, cardiogenesis, tri-snrnp, splicing, fidelity, engaging, activate, ensures
- GSE246916 MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to promote EMT and metastasis in colon cancer 14 samples shares splicing
- GSE248132 LARP6 promotes carcinogenic features of triple negative breast cancer cell line by directly modulating alternative splicing of associated genes 10 samples shares splicing
- GSE281106 Single-cell RNA-seq of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases [scRNAseq_KR_SGI] 352 samples shares splicing
- GSE280974 Single-cell RNA-seq of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases [scRNAseq_JP_RIK] 302 samples shares splicing
- GSE100638 Large-scale tethering of RNA binding proteins discovers alternative splicing regulators 220 samples shares splicing
- GSE252006 Global impact of unproductive splicing on human gene expression. 179 samples shares splicing
- GSE334651 Alternative splicing- and gene fusion-derived neoepitopes in MASLD-associated hepatocellular carcinoma 120 samples shares splicing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.