← BioTransfer GEO Dataset Finder
GEO series

Urine stem cells as a bona fide model to study cartilage associated disease [RNA-Seq]

GSE306729 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/09/29 Platform GPL24676
Summary
Non-invasive cellular models for genetic growth disorders affecting cartilage and bone remain rare, hampering mechanistic studies and the development of personalized therapies. Here, we present urine-derived stem cells (USCs), as a robust in vitro system for human chondrogenesis. Single-cell RNA sequencing of undifferentiated USCs revealed distinct clusters, of which a subset had high stem cell character. After differentiation, USCs underwent osteogenic and chondrogenic lineage with positive marker expression, confirmed by bulk-RNA-Seq. Single cell transcriptomic comparisons with healthy cartilage revealed a healthy cartilage mimicking, chondrocyte-like subcluster. Pseudotime analysis revealed multiple chondrogenic trajectories.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE306729_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1311985 and SRA study SRP613906. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.