Dysregulated ClpP Activation Depletes AML Cells and Restores T-cell Function via Metabolic Competition
Single-cell RNA-seq · mouse · 10 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 3 × Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, vehicle control vs 3 × Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, doxorubicin treatment vs 3 × Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, IMP125 treatmentGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE306851_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1312529. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 10 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9210715 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, vehicle control 1 Single-cell RNA-seq of …
- GSM9210716 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, vehicle control 2 Single-cell RNA-seq of …
- GSM9210717 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, vehicle control 3 Single-cell RNA-seq of …
- GSM9210718 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, doxorubicin treatment 1 Single-cell RNA-seq of …
- GSM9210719 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, doxorubicin treatment 2 Single-cell RNA-seq of …
- GSM9210720 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, doxorubicin treatment 3 Single-cell RNA-seq of …
- GSM9210721 Single-cell RNA-seq of spleen cells from healthy BALB/c mouse
- GSM9210722 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, IMP125 treatment 1 Single-cell RNA-seq of …
- GSM9210723 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, IMP125 treatment 2 Single-cell RNA-seq of …
- GSM9210724 Single-cell RNA-seq of spleen cells from syngeneic AML BALB/c mouse, IMP125 treatment 3 Single-cell RNA-seq of …
- GSE249293 Nonviral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models 12 samples shares aml
- GSE269045 Inflammatory immune modulators of AML lung infiltration and respiratory failure 56 samples shares aml
- GSE299381 KAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [ChIP-Seq] 13 samples shares aml
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares activation
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares activation
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares activation
- GSE236129 Activation of RAS/MEK/ERK signaling drives biliary differentiation in primary liver cancer [112UE] 80 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.