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Serum Amyloid A (SAA) Transcriptomics Sequencing on enteroid

GSE306974 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/20 Platform GPL34284
Summary
The 104 aa protein Serum Amyloid A (SAA) is a prominent member of the acute phase response (APR) a remarkably conserved and stereotyped set of serum protein changes associated with inflammation and other stimuli. N-terminal fragments of SAA can form fibrils that can accumulate in organs (“amyloidosis”). No specific biologic function has been identified for SAA; it has been considered an inert “biomarker.” In contrast to this perception of passivity, we report that exposure to both N-terminal decapeptides and intact SAA monomers can induce multiple transcripts in both enteroids and HEK293 cells. The spectrum of transcripts prominently includes proteins related to inflammation and NF-κB control, specifically NFKB1A, TNFA1P3 and IER3. SAA thus can act directly through specific transcription to alter cellular physiology with direct effects on inflammation, likely helping explain its remarkable evolutionary conservation as part of primordial defense.
Published in
Serum Amyloid A (SAA) induces transcription affecting inflammation
Sack GH Jr, Yun J, Talbot CC Jr et al. · PloS one 2026 · PMID 41712650 · doi:10.1371/journal.pone.0341858
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Also filed as BioProject PRJNA1313133 and SRA study SRP614959. Searching any of these in the dataset finder brings you back here.

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