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Gene expression profile of B55a/PPP2R2A knocked-down Parkin-expressing HeLa cells

GSE307113 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/07 Platform GPL23227
Summary
Or study identified the PP2A-B55a/PPP2R2A Ser-Thr phosphatase as a regulator of Parkin-dependent mitophagy and mitochondrial biogenesis. HeLa cells expressing Parkin and knocked-down for B55a/PPP2R2A induce a lysosome- and mitochondria-related transcriptional programmes down-stream TFEB and PGC-1a transcription factor activation.
Published in
The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis
Cianfanelli V, Nanni M, Corrà S et al. · Science advances 2025 · PMID 41042873 · doi:10.1126/sciadv.adw7376
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Direct links to NCBI, no account and no request form: the whole study as GSE307113_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1314588 and SRA study SRP617688. Searching any of these in the dataset finder brings you back here.

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