GEO series
CDK10 suppression sensitizes cells to CDK12/13 blockade
GSE307213
Homo sapiens
Expression profiling by high throughput sequencing
48 samples
2026/06/09
GPL28038
Summary
A CRISPR screen with a CDK12/13 inhibitor identified CDK10 as a modulator of CDK12/13 blockade. CDK10 KO cells in OVCA and BRCA showed higher sensitivity to CDK12/13 inhibitors and increased apoptosis, compared to wild type cells. To investigate the effects on transcription, CDK10 KO cells with or without CDK12/13 inhibitor treatment were analyzed by RNA-sequencing.
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Paper (PMID 42270604) ↗
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