c-JUN Enhances CRISPR Knock-In anti-B7-H3 CAR T-cell Function for Treatment of Small Cell Lung Cancer and thoracic SMARCA4-deficient undifferentiated tumors
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumorsCell reports. Medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307259_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1306191 and SRA study SRP609027. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9220045 RNA-seq of B7H3-CAR T cells from healthy human donor 1, no TGFb
- GSM9220046 RNA-seq of B7H3-CAR T cells from healthy human donor 1, TGFb-treated
- GSM9220047 RNA-seq of c-Jun-OE B7H3-CAR T cells from healthy human donor 1, no TGFb
- GSM9220048 RNA-seq of c-Jun-OE B7H3-CAR T cells from healthy human donor 1, TGFb-treated
- GSM9220049 RNA-seq of B7H3-CAR T cells from healthy human donor 2, no TGFb
- GSM9220050 RNA-seq of B7H3-CAR T cells from healthy human donor 2, TGFb-treated
- GSM9220051 RNA-seq of c-Jun-OE B7H3-CAR T cells from healthy human donor 2, no TGFb
- GSM9220052 RNA-seq of c-Jun-OE B7H3-CAR T cells from healthy human donor 2, TGFb-treated
- GSM9220053 RNA-seq of B7H3-CAR T cells from healthy human donor 3, no TGFb
- GSM9220054 RNA-seq of B7H3-CAR T cells from healthy human donor 3, TGFb-treated
- GSM9220055 RNA-seq of c-Jun-OE B7H3-CAR T cells from healthy human donor 3, no TGFb
- GSM9220056 RNA-seq of c-Jun-OE B7H3-CAR T cells from healthy human donor 3, TGFb-treated
- GSE262597 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma 56 samples same disease briefing · shares car
- GSE294644 Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma 7 samples same disease briefing · shares car
- GSE138474 Single-cell analyses reveal increasing intratumoral heterogeneity as an essential component of treatment resistance in small cell lung cancer 43 samples same disease briefing · shares treatment
- GSE64766 Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC 16 samples same disease briefing · shares car
- GSE233820 PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through depression of chemokine translation in small cell lung cancer 12 samples same disease briefing · shares enhances
- GSE280682 CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer 6 samples same disease briefing · shares crispr
- GSE272002 LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC 324 samples same disease briefing
- GSE208446 Small cell lung cancer responds to inhibition of Jumonji enzyme in vitro and in vivo 90 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.