RNA-sequencing of Endothelial Cell Lines Expressing TIE2 WT or Mutant TIE2-L914F
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × HUVEC NT, vs 4 × HUVEC TIE2-L914F, vs 4 × HUVEC TIE2-WT,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous MalformationArteriosclerosis, thrombosis, and vascular biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307395_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1320648 and SRA study SRP617751. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9223315 HUVEC NT, rep 1 HUVEC NT,
- GSM9223316 HUVEC NT, rep 2 HUVEC NT,
- GSM9223317 HUVEC NT, rep 3 HUVEC NT,
- GSM9223318 HUVEC NT, rep 4 HUVEC NT,
- GSM9223319 HUVEC TIE2-L914F, rep 1 HUVEC TIE2-L914F,
- GSM9223320 HUVEC TIE2-L914F, rep 2 HUVEC TIE2-L914F,
- GSM9223321 HUVEC TIE2-L914F, rep 3 HUVEC TIE2-L914F,
- GSM9223322 HUVEC TIE2-L914F, rep 4 HUVEC TIE2-L914F,
- GSM9223323 HUVEC TIE2-WT, rep 1 HUVEC TIE2-WT,
- GSM9223324 HUVEC TIE2-WT, rep 2 HUVEC TIE2-WT,
- GSM9223325 HUVEC TIE2-WT, rep 3 HUVEC TIE2-WT,
- GSM9223326 HUVEC TIE2-WT, rep 4 HUVEC TIE2-WT,
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.