GEO series
RNA-seq analysis of NCI-H1693 cells treated with the selective SMARCA2 degrader PRT3789
GSE307424
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2025/09/12
GPL20795
Summary
The goal of this study was to examine the transcriptional consequences of selective SMARCA2 degradation in a SMARCA4-deficient non-small cell lung cancer (NSCLC) model. NCI-H1693 cells were treated with the SMARCA2 degrader PRT3789 (50 nM) or vehicle control for 6 h, 48 h, and 72 h. RNA-seq was performed to identify changes in gene expression that could reveal pathways associated with synthetic lethality and clarify the mechanism of action of SMARCA2 degraders in the absence of SMARCA4.
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