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Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy

GSE307443 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/09/14 Platform GPL17303
Summary
The extracellular matrix protein laminin-α2 is essential for preserving the integrity of skeletal muscle fibers during contraction. Its importance is reflected by the severe, congenital LAMA2-related muscular dystrophy (LAMA2 MD) caused by loss-of-function mutations in the LAMA2 gene. While laminin-α2 has an established role in structurally supporting muscle fibers, it remains unclear whether it exerts additional functions that contribute to the maintenance of skeletal muscle integrity. Submitted transcriptomic data represents gene expression profile of control and LAMA2-deficient human myogenic precursor cells derived from induced pluripotent stem cells which was analyzed to better understand the role of laminin-α2 in human cells.
Published in
Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy
McGowan TJ, Reinhard JR, Lewerenz N et al. · Nature communications 2025 · PMID 41309582 · doi:10.1038/s41467-025-65703-1
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Also filed as BioProject PRJNA1321711 and SRA study SRP618338. Searching any of these in the dataset finder brings you back here.

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