NAT10-Dependent N4-acetylcytidine (ac4C) on R-loops Drive Glioblastoma Tumorigenesis and Stemness
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 38 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- GlioblastomaThis series is part of our curated briefing on it.
- Samples
- 38 samples: 33 distinct titles, 5 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NAT10-dependent N(4)-acetylcytidine reprograms R-loops and promotes cancer stem cell growthCell reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307601_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1322362 and SRA study SRP618727. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 38 sample titles: 33 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9227698 GSC23 H3K27ac shCONT IP
- GSM9227699 GSC23 H3K27ac shNAT10 IP
- GSM9227700 GSC387 H3K27ac shCONT IP
- GSM9227701 GSC387 H3K27ac shNAT10 IP
- GSM9227702 GSC23 H3K27ac shCONT input
- GSM9227703 GSC23 H3K27ac shNAT10 input
- GSM9227704 GSC387 H3K27ac shCONT input
- GSM9227705 GSC387 H3K27ac shNAT10 input
- GSM9227710 RIP GSC23 shCONT
- GSM9227711 RIP GSC387 shCONT
- GSM9227712 RIP GSC23 shNAT10
- GSM9227713 RIP GSC387 shNAT10
- GSM9227714 RIP GSC23 shCONT input
- GSM9227715 RIP GSC387 shCONT input
- GSM9227716 GSC23 shCONT rep1
- GSM9227717 GSC23 shCONT rep2
- GSM9227718 GSC23 shNAT10 rep1
- GSM9227719 GSC23 shNAT10 rep2
- GSM9227720 GSC387 shCONT rep1
- GSM9227721 GSC387 shCONT rep2
- GSM9227722 GSC387 shNAT10 rep1
- GSM9227723 GSC387 shNAT10 rep2
- GSM9227738 RRChIP GSC23
- GSM9227739 RRChIP GSC387
- GSM9227740 RRChIP DGC23
- GSM9227741 RRChIP NSC11
- GSM9227742 RRChIP GSC23 shCONT
- GSM9227743 RRChIP GSC23 shNAT10
- GSM9227744 RRChIP GSC387 shCONT
- GSM9227745 RRChIP GSC387 shNAT10
- GSM9227746 RRChIP GSC23 input
- GSM9227747 RRChIP GSC387 input
- GSM9227748 RRChIP DGC23 input
- GSM9227749 RRChIP NSC11 input
- GSM9227750 RRChIP GSC23 shCONT input
- GSM9227751 RRChIP GSC23 shNAT10 input
- GSM9227752 RRChIP GSC387 shCONT input
- GSM9227753 RRChIP GSC387 shNAT10 input
- GSE107560 Ivy Glioblastoma Atlas Project 305 samples same disease briefing · shares glioblastoma
- GSE13041 Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age 267 samples same disease briefing · shares glioblastoma
- GSE10878 Integrative Genome-wide Analysis of Glioblastoma. 60 samples same disease briefing · shares glioblastoma
- GSE112650 SOX4/11 Enhances NGN2 Reprogramming Glioblastoma Cells into Neuron Cells by Modulating RhoA and CDC42/RAC1 Pathway Activity 30 samples same disease briefing · shares glioblastoma
- GSE112648 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 18 samples same disease briefing · shares glioblastoma
- GSE112645 SOXC factors as suppressors modulate Rho activity to promote neuronal reprogramming of human glioblastoma cells 12 samples same disease briefing · shares glioblastoma
- GSE115459 Exosome-transmitted RVT1 from reactive astrocytes promotes recurrence glioblastoma proliferation 9 samples same disease briefing · shares glioblastoma
- GSE131928 single cell RNA-seq analysis of adult and paediatric IDH-wildtype Glioblastomas 2 samples same disease briefing · shares glioblastoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.