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Gene expression analysis of cancer-associated fibroblasts from scirrhous gastric cancers and non-scirrhous gastric cancers

GSE307738 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/10 Platform GPL20795
Summary
Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer-associated fibroblasts (CAFs). We here aimed to explore the molecular basis for scirrhous CAFs and their origin. The aggressive phenotype of scirrhous CAFs were associated with activation of TGFβ1 and NF-kB, along with increased expression of their downstream genes.
Published in
Super-Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non-Cancerous Tissues
Yasukawa Y, Hattori N, Liu YY et al. · Cancer science 2026 · PMID 42070972 · doi:10.1111/cas.70408
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Also filed as BioProject PRJNA1327234 and SRA study SRP619065. Searching any of these in the dataset finder brings you back here.

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