GEO series
A Unique Pediatric Activated T-cell Acute Liver Failure Endotype Characterized by Perforin and Interferon Gamma Expressing Circulating CD8 Tissue Resident Memory T-cells.
GSE307970
Homo sapiens
Expression profiling by high throughput sequencing; Other
10 samples
2026/03/31
GPL24676
Summary
Activated T-cell Pediatric Acute Liver Failure (TC-PALF) is the most common cause of non-acetaminophen PALF with poor transplant-free survival. Livers in TC-PALF are infiltrated by effector cytotoxic T lymphocytes with markers of tissue-resident memory function (CD8 Trm) and an interferon gamma (IFNg) transcriptional signature. The PALF-Immune Response Network (PALF-IRN) and the prospective TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) clinical trial (NCT04862221) aim to characterize the TC-PALF immune pathology and utility of T-cell directed therapy to improve transplant free survival.
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Paper (PMID 41921202) ↗
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