GEO series
Epigenetic modification, as a distinctive therapeutic molecule for Parkinson’s disease gene therapy.
GSE308116
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
17 samples
2025/11/30
GPL34328GPL21273
Summary
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disruption of cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor function in an animal model of PD.
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