Comprehensive mass spectrometry screening-derived atlas of HDAC inhibitors reveals histone specific acetylation changes [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Comprehensive mass spectrometry screening-derived atlas of HDAC inhibitors reveals histone-specific acetylation changesCell reports · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308263_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1329324 and SRA study SRP620870. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9241239 HeLa cells, DMSO-control, 24h, biol rep 1, H2A.Zac, ChIP
- GSM9241240 HeLa cells, DMSO-control, 24h, biol rep 2, H2A.Zac, ChIP
- GSM9241241 HeLa cells, DMSO-control, 24h, Input
- GSM9241242 HeLa cells, Entinostat-treatment, 24h, biol rep 1, H2A.Zac, ChIP
- GSM9241243 HeLa cells, Entinostat-treatment, 24h, biol rep 2, H2A.Zac, ChIP
- GSM9241244 HeLa cells, Entinostat-treatment, 24h, Input
- GSM9241245 MDA-MB-231, DMSO-control, 24h, biol rep 1, H2A.Zac, ChIP
- GSM9241246 MDA-MB-231, DMSO-control, 24h, biol rep 2, H2A.Zac, ChIP
- GSM9241247 MDA-MB-231, DMSO-control, 24h, Input
- GSM9241248 MDA-MB-231, Entinostat-treatment, 24h, biol rep 1, H2A.Zac, ChIP
- GSM9241249 MDA-MB-231, Entinostat-treatment, 24h, biol rep 2, H2A.Zac, ChIP
- GSM9241250 MDA-MB-231, Entinostat-treatment, 24h, Input
- GSE308262 Comprehensive mass spectrometry screening-derived atlas of HDAC inhibitors revelas histone specific acetylation chnages [RNA-seq] 12 samples shares hdac, screening-derived, spectrometry, acetylation, inhibitors, specific, histone
- GSE270024 RCOR2 downregulates CIITA via HDAC1-mediated histone deacetylation in cancer cells [ChIP-seq] 12 samples shares hdac, acetylation, chip-seq, histone
- GSE302670 Enhanced efficacy of a specific HDAC3 inhibitor in combination with 5-Azacitidine against diffuse large B-cell lymphoma [ChIP-seq] 13 samples shares hdac, specific, chip-seq
- GSE287728 BRD2 bridging TFIID and histone acetylation in transcriptional initiation [ChIP-Seq] 50 samples shares acetylation, chip-seq, histone
- GSE286492 CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks 38 samples shares acetylation, chip-seq, histone
- GSE256473 SOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape (ChIP-seq) 10 samples shares acetylation, chip-seq, histone
- GSE253743 Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer [ChIP-seq, Cut&Tag, ATAC-seq] 41 samples shares hdac, chip-seq
- GSE263573 HDAC5 Depletion Promotes Hyper-Acetylation of FOXA1 and Potentiating HIF1α Transcriptional Activation in Pancreatic Cancer 32 samples shares hdac, acetylation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.