P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × A485 Flow vs 3 × A485 Static vs 3 × DMSO Flow vs 3 × DMSO StaticGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- P300 Modulates Endothelial Mechanotransduction of Fluid Shear StressCellular and molecular bioengineering · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308342_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1330236 and SRA study SRP621198. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9242571 A485 Flow Replicate1 A485 Flow
- GSM9242572 A485 Flow Replicate2 A485 Flow
- GSM9242573 A485 Flow Replicate3 A485 Flow
- GSM9242574 A485 Static Replicate1 A485 Static
- GSM9242575 A485 Static Replicate2 A485 Static
- GSM9242576 A485 Static Replicate3 A485 Static
- GSM9242577 DMSO Flow Replicate1 DMSO Flow
- GSM9242578 DMSO Flow Replicate2 DMSO Flow
- GSM9242579 DMSO Flow Replicate3 DMSO Flow
- GSM9242580 DMSO Static Replicate1 DMSO Static
- GSM9242581 DMSO Static Replicate2 DMSO Static
- GSM9242582 DMSO Static Replicate3 DMSO Static
- GSE294621 Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress 74 samples shares endothelial, stress, shear
- GSE311520 Hutchinson Gilford Progeria Syndrome alters the endothelial genetic response to laminar shear stress 24 samples shares endothelial, stress, shear
- GSE303084 Pressure Points: Endothelial Responses to Hemodynamic Stress in Health and Pulmonary Arterial Hypertension 72 samples shares endothelial, stress
- GSE301613 ACSS2 modulates endothelial glycolysis in angiogenesis 9 samples shares endothelial, modulates
- GSE304253 Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [SLAM-Seq] 35 samples shares p300
- GSE275778 AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer [RNA-seq: 22RV1] 20 samples shares p300
- GSE266253 DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming 12 samples shares p300
- GSE245969 EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells 122 samples shares p300
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.