Spatial biology reveals macrophage dysfunction in immunosuppressed non-melanoma skin cancer
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 16 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancerCell · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308361_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1330270. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9244045 SC10-64_BCC_IS_scATAC-seq
- GSM9244046 SC3-38_BCC_IC_scATAC-seq
- GSM9244047 SC4-25_BCC_IC_scATAC-seq
- GSM9244048 SC5-60_SCC_IS_scATAC-seq
- GSM9244049 SC6-68_BCC_IS_scATAC-seq
- GSM9244050 SC7-19_SCC_IS_scATAC-seq
- GSM9244051 SC8-4R_BCC_IC_scATAC-seq
- GSM9244052 SC9-54_BCC_IC_scATAC-seq
- GSM9244053 SC10-64_BCC_IS_scRNA-seq
- GSM9244054 SC3-38_BCC_IC_scRNA-seq
- GSM9244055 SC4-25_BCC_IC_scRNA-seq
- GSM9244056 SC5-60_SCC_IS_scRNA-seq
- GSM9244057 SC6-68_BCC_IS_scRNA-seq
- GSM9244058 SC7-19_SCC_IS_scRNA-seq
- GSM9244059 SC8-4R_BCC_IC_scRNA-seq
- GSM9244060 SC9-54_BCC_IC_scRNA-seq
- GSE316922 Spatial biology reveals macrophage dysfunction in immunosuppressed non-melanoma skin cancer 36 samples shares immunosuppressed, non-melanoma, dysfunction, macrophage, spatial, biology, skin
- GSE306129 Spatial biology reveals macrophage dysfunction in immunosuppressed non-melanoma skin cancer [spatial_ATAC] 28 samples shares immunosuppressed, non-melanoma, dysfunction, macrophage, spatial, biology, skin
- GSE312129 Single-nuclei multiome and spatial analyses of early, untreated SSc skin identify a proinflammatory vascular niche of macrophage-fibroblast signaling 38 samples shares macrophage, spatial, skin
- GSE319722 Spatial dynamics links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in microsatellite stable colorectal cancer 117 samples shares macrophage, spatial
- GSE255312 Spatial transcriptomics landscape for liver from patients with metabolic dysfunction-associated steatohepatitis (MASH) 72 samples shares dysfunction, spatial
- GSE292848 Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis 25 samples shares dysfunction, skin
- GSE294277 Integrative single cell RNA-sequencing and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis 22 samples shares macrophage, spatial
- GSE317605 A Phase II Trial of Pembrolizumab plus Granulocyte Macrophage Colony Stimulating Factor in Advanced Biliary Cancer [CITE-Seq] 168 samples shares macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.