Super-enhancer–mediated SMAD3–NR2F2–ID3 transcriptional complex orchestrates Osimertinib resistance in non-small cell lung cancer [CUT&Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 15 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A Non-Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non-Small Cell Lung CancerAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308412_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1330364 and SRA study SRP621365. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9244957 Patient 1-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244958 Patient 2-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244959 Patient 3-NSCLC, pre-treatment, H3K27ac (CUT&Tag)
- GSM9244960 Patient 4-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244961 Patient 5-NSCLC, pre-treatment, H3K27ac (CUT&Tag)
- GSM9244962 Patient 6-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244963 Patient 7-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244964 Patient 8-NSCLC, pre-treatment, H3K27ac (CUT&Tag)
- GSM9244965 Patient 9-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244966 Patient 10-NSCLC, post-treatment, H3K27ac (CUT&Tag)
- GSM9244967 HCC827 cells, Osimertinib-resistant, ID3 (CUT&Tag)
- GSM9244968 HCC827 cells, Osimertinib-resistant, H3K4me1 (CUT&Tag)
- GSM9244969 HCC827 cells, Osimertinib-resistant, H3K4me3 (CUT&Tag)
- GSM9244970 HCC827 cells, Osimertinib-resistant, NR2F2 (CUT&Tag)
- GSM9244971 HCC827 cells, Osimertinib-resistant, SMAD3 (CUT&Tag)
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples same disease briefing
- GSE17958 Affymetrix SNP array data for 47 lung squamous cell carcinoma and 40 esophageal squamous cell carcinoma samples. 87 samples same disease briefing
- GSE114761 Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Signature Predicts Metastasis-Free Survival in Non-Small Cell Lung Cancer. 42 samples same disease briefing
- GSE127465 Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species 40 samples same disease briefing
- GSE104244 Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents 33 samples same disease briefing
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples same disease briefing
- GSE27389 Substitutions in the KRas oncogene determine protein behavior: Implications for signaling and clinical outcome. 22 samples same disease briefing
- GSE117570 Reprogramming of Tumor-infiltrating Immune Cells in Early Stage of NSCLC 8 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.