GEO series
CYP450-Mediated Detoxification and NF-κB/NLRP3-Driven Mechanisms in Emodin-Induced Hepatotoxicity in vitro and in vivo
GSE308606
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2025/09/24
GPL24247
Summary
Emodin, a bioactive compound abundant in Chinese medicinal herbs, possesses broad therapeutic potential but raises safety concerns due to conflicting reports of hepatotoxicity. This study investigated the toxicological mechanisms underlying emodin-induced liver injury. We showed that emodin induced dose-dependent cytotoxicity and hepatic injury in HepG2 cells. Moreover, emodin (400 mg/kg) induced hepatotoxicity in mice after administered for three weeks.This study delineates the metabolic detoxification pathways of emodin and elucidates its toxicological mechanisms.
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