Molecular Mechanisms of the MLL4 Complex in H3K4 Methylation and p53-Dependent Transcription Activation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308630_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1331736 and SRA study SRP621857. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 8 replicated groups read from 26 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9241275 MLL4WT_rep1 MLL4WT
- GSM9241276 MLL4WT_rep2 MLL4WT
- GSM9241277 MLL4WT_rep3 MLL4WT
- GSM9241278 MLL4KO_rep1 MLL4KO
- GSM9241279 MLL4KO_rep2 MLL4KO
- GSM9241280 MLL4KO_rep3 MLL4KO
- GSM9246356 H3K4me1_MLL4WT
- GSM9246357 H3K4me1_MLL4KO
- GSM9246358 H3K4me3_MLL4WT_rep1 H3K4me3_MLL4WT
- GSM9246359 H3K4me3_MLL4KO_rep1 H3K4me3_MLL4KO
- GSM9246360 H3K27ac_MLL4WT_rep1 H3K27ac_MLL4WT
- GSM9246361 H3K27ac_MLL4KO_rep1 H3K27ac_MLL4KO
- GSM9246362 MLL4_MLL4WT
- GSM9246363 MLL4_MLL4KO
- GSM9246364 p53_MLL4WT_rep1 p53_MLL4WT
- GSM9246365 p53_MLL4KO_rep1 p53_MLL4KO
- GSM9246366 H3K4me3_MLL4WT_rep2 H3K4me3_MLL4WT
- GSM9246367 H3K4me3_MLL4KO_rep2 H3K4me3_MLL4KO
- GSM9246368 MLL1_MLL4WT
- GSM9246369 MLL1_MLL4KO
- GSM9246370 Input_MLL4WT
- GSM9246371 Input_MLL4KO
- GSM9246372 p53_MLL4WT_rep2 p53_MLL4WT
- GSM9246373 p53_MLL4KO_rep2 p53_MLL4KO
- GSM9246374 H3K27ac_MLL4WT_rep2 H3K27ac_MLL4WT
- GSM9246375 H3K27ac_MLL4KO_rep2 H3K27ac_MLL4KO
- GSE254366 Epigenome reprogramming through H3K27 and H3K4 trimethylation as a resistance mechanism to DNA methylation inhibition in BRAFV600E-mutated CRC. 36 samples shares h3k4, methylation
- GSE273326 A trimeric USP11-USP7-TCEAL1 complex stabilizes paused RNAPII to sustain oncogenic transcription 63 samples shares transcription, complex
- GSE272562 Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery 46 samples shares transcription, activation
- GSE289465 Targeting a Galectin-3/EGR1 transcriptional complex inhibits the pro-metastatic signature in TRIM49-deficient gastric adenocarcinoma 18 samples shares transcription, complex
- GSE244403 cGAS-STING axis activation drove inflammatory phenotype acquisition of senescent nucleus pulposus cells via p65-mediated transcriptional modulation 12 samples shares transcription, activation
- GSE280574 mChIP-seq for high-throughput epigenomic profiling reveals a decoupling of H2A.Z and H3K4me3 in cancer 576 samples shares h3k4
- GSE339365 Genome-wide H3K4me3 profiling of circulating immune cells reveals dynamic epigenetic reprogramming during acute critical COVID-19 120 samples shares h3k4
- GSE182605 Integrative gene regulatory analysis reveals transcriptional mechanisms required in mature human hepatocytes and during in vitro hepatocyte differentiation 35 samples shares transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.