GEO series

CD4+ T cells' immune response during the early phase of infection with Schistosoma japonicum

GSE308662 Alexandromys fortis; Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/02/18 Platform GPL36270Platform GPL24247

Summary

Single-cell transcriptome analysis reveals that the CD4+ T cells' immune response was more intense in the non-permissive host Microtus fortis than in the permissive host Kunming mice during the early phase of infection with Schistosoma japonicum We have employed a single-cell sequencing approach using Singleron scRNA-seq to explore the immune response of M. fortis and Kunming mice to S. japonicum. The study allowed us to decipher M. fortis PBMC heterogeneity and provide detailed information on the transcriptome profile of the different cell types following exposure to S. japonicum.

Published in

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

Dibo N, Zhou Z, Liu X et al. · Frontiers in cellular and infection microbiology 2025 · PMID 41675929 · doi:10.3389/fcimb.2025.1739541

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Direct links to NCBI, no account and no request form: the whole study as GSE308662_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1331834 and SRA study SRP622759. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41675929) ↗

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