GEO series
Effect of the overexpression of the NOTCH inhibitor ligand DLL3 in low grade astrocytoma cell line LGG275
GSE308910
Homo sapiens
Expression profiling by high throughput sequencing
14 samples
2026/01/13
GPL29480
Summary
Astrocytoma are known to presents a cellular heterogeneity consisting of three identified subpopulation: "astrocyte-like", "oligodendrocyte-like" and "NPC-like" cells. Among these populations, "astrocyte-like" cells show plasticity and can transit to an "oligodendrocyte-like" state. Activation of NOTCH pathways induce an transition into astrocyte-like state. To investigate the effect of NOTCH inhition on cell plasticity, we overexpressed DLL3, the main ligand inhibitor of NOTCH.
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