GEO series
Epigenetic Profiling of T-bet/Runx3 Double Knockout Models via ATAC-seq and Cut&Run in Antiviral CD8+T Cells
GSE308991
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
9 samples
2026/08/04
GPL21103
Summary
The rapid acquisition of cytotoxic functions while maintaining lineage fidelity in effector CD8? T cells relies on precise transcriptional control by T-bet and Runx3. Despite their critical role, the integrated regulatory logic of these factors remained unclear due to limited chromatin accessibility and binding data. This work clarifies their distinct and overlapping contributions through targeted genetic perturbations.
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