GEO series
Transcriptional Landscape Analysis of T-bet/Runx3 in Antiviral CD8+ T Cells via Single- and Double-Knockout RNA-seq
GSE308992
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/08/04
GPL21103
Summary
Effector CD8+ T cells require tight coordination of cytotoxic gene expression programs with lineage maintenance. T-bet and Runx3 are central to this process, but their combined transcriptional control mechanisms were poorly understood due to sparse transcriptional datasets. This study dissects their cooperative and distinct roles through systematic RNA-seq profiling of knockout models.
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