HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc- Driven Small Cell Lung Cancer [ATAC-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × ATACseq_RPM_tumor_Ctrl vs 3 × ATACseq_RPM_tumor_aPD1 vs 3 × ATACseq_RPM_tumor_ent vs 3 × ATACseq_RPM_tumor_aPD1_entGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc-driven small cell lung cancerMolecular cancer therapeutics · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309213_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1334351 and SRA study SRP627210. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9263235 ATACseq_RPM_tumor_Ctrl_1 ATACseq_RPM_tumor_Ctrl
- GSM9263236 ATACseq_RPM_tumor_Ctrl_2 ATACseq_RPM_tumor_Ctrl
- GSM9263237 ATACseq_RPM_tumor_Ctrl_3 ATACseq_RPM_tumor_Ctrl
- GSM9263238 ATACseq_RPM_tumor_aPD1_1 ATACseq_RPM_tumor_aPD1
- GSM9263239 ATACseq_RPM_tumor_aPD1_2 ATACseq_RPM_tumor_aPD1
- GSM9263240 ATACseq_RPM_tumor_aPD1_3 ATACseq_RPM_tumor_aPD1
- GSM9263241 ATACseq_RPM_tumor_ent_1 ATACseq_RPM_tumor_ent
- GSM9263242 ATACseq_RPM_tumor_ent_2 ATACseq_RPM_tumor_ent
- GSM9263243 ATACseq_RPM_tumor_ent_3 ATACseq_RPM_tumor_ent
- GSM9263244 ATACseq_RPM_tumor_aPD1_ent_1 ATACseq_RPM_tumor_aPD1_…
- GSM9263245 ATACseq_RPM_tumor_aPD1_ent_2 ATACseq_RPM_tumor_aPD1_…
- GSM9263246 ATACseq_RPM_tumor_aPD1_ent_3 ATACseq_RPM_tumor_aPD1_…
- GSE300887 Sequential Platinum and PARP Inhibition Enhances PD1 Immunotherapy Efficacy in Murine Brca2 Mutated Pancreatic Cancer [RNAseq_1] 13 samples shares immunotherapy, inhibition, enhances
- GSE309033 Combined BET Bromodomain and DNMT Inhibition Targets Lineage Plasticity in Prostate Cancer [BETi_DNMTi_mouse_RNAseq] 51 samples shares inhibition, plasticity
- GSE290756 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis 50 samples shares plasticity, driven
- GSE327645 BACH1 acts as a pioneer repressor to enable macrophage plasticity and adaptation across tissues and inflammatory contexts [RNA-seq/ATAC-seq] 28 samples shares plasticity, atac-seq
- GSE308216 A biohybrid chiral hydrogel enhances preclinical postoperative glioblastoma therapy by multi-pronged inhibition of tumor stemness 15 samples shares inhibition, enhances
- GSE293383 Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity [RNA-seq] 12 samples shares plasticity, enhances
- GSE275917 Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation [ChIP-seq] 17 samples shares hdac
- GSE255887 HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection 76 samples shares hdac
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.