CK2-mediated DEK Phosphorylation Drives PBX3 Overexpression: A Core Event in Hematopoietic Stem Cell-to-Leukemia Stem Cell Transformation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 53 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 53 samples: 22 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phosphorylated DEK sustains leukemia stem cells by enabling PBX3-driven transcriptional reprogrammingBlood · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309285_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1335085 and SRA study SRP627107. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 51 samples.
How we read this: 22 replicated groups read from 53 sample titles; they account for 51 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9262664 L-GMP_FL_1 L-GMP_FL
- GSM9262665 L-GMP_FL_2 L-GMP_FL
- GSM9262666 L-GMP_FL_3 L-GMP_FL
- GSM9262667 L-GMP_FL_4 L-GMP_FL
- GSM9262668 L-GMP_KO_1 L-GMP_KO
- GSM9262669 L-GMP_KO_2 L-GMP_KO
- GSM9262670 L-GMP_KO_3 L-GMP_KO
- GSM9262671 L-GMP_KO_4 L-GMP_KO
- GSM9262672 ATAC_L-GMP_FL_1 ATAC_L-GMP_FL
- GSM9262673 ATAC_L-GMP_FL_2 ATAC_L-GMP_FL
- GSM9262674 ATAC_L-GMP_KO_1 ATAC_L-GMP_KO
- GSM9262675 ATAC_L-GMP_KO_2 ATAC_L-GMP_KO
- GSM9264368 CUT-Tag_L-GMP_WT_DEK_1 CUT-Tag_L-GMP_WT_DEK
- GSM9264369 CUT-Tag_L-GMP_WT_DEK_2 CUT-Tag_L-GMP_WT_DEK
- GSM9264370 CUT-Tag_L-GMP_4S-A_DEK_1
- GSM9264371 CUT-Tag_L-GMP_4S-A _DEK_2
- GSM9264372 CUT-Tag_L-GMP_WT_PBX3_1 CUT-Tag_L-GMP_WT_PBX3
- GSM9264373 CUT-Tag_L-GMP_WT_PBX3_2 CUT-Tag_L-GMP_WT_PBX3
- GSM9264374 CUT-Tag_L-GMP_WT_GABPA_1 CUT-Tag_L-GMP_WT_GABPA
- GSM9264375 CUT-Tag_L-GMP_WT_GABPA_2 CUT-Tag_L-GMP_WT_GABPA
- GSM9264376 CUT-Tag_L-GMP_KO_GABPA_1 CUT-Tag_L-GMP_KO_GABPA
- GSM9264377 CUT-Tag_L-GMP_KO_GABPA_2 CUT-Tag_L-GMP_KO_GABPA
- GSM9264378 CUT-Tag_L-GMP_4S-A_GABPA_1 CUT-Tag_L-GMP_4S-A_GABPA
- GSM9264379 CUT-Tag_L-GMP_4S-A_GABPA_2 CUT-Tag_L-GMP_4S-A_GABPA
- GSM9700762 ATAC_L-GMP_FL_3 ATAC_L-GMP_FL
- GSM9700763 ATAC_L-GMP_KO_3 ATAC_L-GMP_KO
- GSM9700764 ATAC_L-GMP_4S-A_1 ATAC_L-GMP_4S-A
- GSM9700765 ATAC_L-GMP_4S-A_2 ATAC_L-GMP_4S-A
- GSM9700766 ATAC_MOLM13_shControl_1 ATAC_MOLM13_shControl
- GSM9700767 ATAC_MOLM13_shControl_2 ATAC_MOLM13_shControl
- GSM9700768 ATAC_MOLM13_shDEK_1 ATAC_MOLM13_shDEK
- GSM9700769 ATAC_MOLM13_shDEK_2 ATAC_MOLM13_shDEK
- GSM9700770 ATAC_MOLM13_4S-A_1 ATAC_MOLM13_4S-A
- GSM9700771 ATAC_MOLM13_4S-A_2 ATAC_MOLM13_4S-A
- GSM9700772 CUT-Tag_L-GMP_FL_PBX3_1 CUT-Tag_L-GMP_FL_PBX3
- GSM9700773 CUT-Tag_L-GMP_FL_PBX3_2 CUT-Tag_L-GMP_FL_PBX3
- GSM9700774 CUT-Tag_L-GMP_KO_PBX3_1 CUT-Tag_L-GMP_KO_PBX3
- GSM9700775 CUT-Tag_L-GMP_KO_PBX3_2 CUT-Tag_L-GMP_KO_PBX3
- GSM9700776 CUT-Tag_L-GMP_WT_DEK_3 CUT-Tag_L-GMP_WT_DEK
- GSM9700777 CUT-Tag_L-GMP_KO_DEK_1 CUT-Tag_L-GMP_KO_DEK
+ 13 more — browse all 53 samples with per-sample file links →
- GSE267491 Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia 91 samples shares dek
- GSE244843 Relaxin Attenuates the Genomic Actions and Biological Effects of Estrogens in the Myometrium by Reducing Estrogen Receptor Alpha Phosphorylation 56 samples shares phosphorylation
- GSE234614 Osteosarcoma uses host-derived growth factors to drive ERK phosphorylation and MCL1 expression to survive in the metastatic environment 5 samples shares phosphorylation
- GSE292019 Phosphorylation of CSDE1 drives ribosome interactions with implications for cancer malignancy 4 samples shares phosphorylation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.