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CD4+ T-Cells Mediate CART Immune-Related Adverse Events (CirAE) Following BCMA CART Therapy

GSE309403 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/27 Platform GPL34281
Summary
We employed single-cell RNA sequencing (scRNA-seq) using the 10x Genomics platform to study the immune landscape of CAR T cells in the peripheral blood (PBMC) and cerebrospinal fluid (CSF) of patients treated with Cilta-cel who developed CAR T-cell immune-related adverse events (CiRAE). CAR T cells were captured and profiled across both compartments. This study offers insights into how CAR T cell phenotypes and functional states diverge between the periphery and central nervous system during inflammatory neurotoxicity.
Published in
CD4(+) T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy
Ho M, Paruzzo L, Noll JH et al. · Nature medicine 2026 · PMID 41540109 · doi:10.1038/s41591-025-04121-8
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Also filed as BioProject PRJNA1336040 and SRA study SRP629414. Searching any of these in the dataset finder brings you back here.

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