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RNA alterations induced by influenza infection

GSE309539 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/29 Platform GPL34281
Summary
The H13N2 subtype avian influenza virus (AIV) is a virus with cross-species transmission capability, which was previously known to mainly infect waterfowl. However, recent studies have confirmed that this virus can also infect poultry and mammals. This cross-species transmission ability has raised widespread concerns about its potential public health threat. In this study, we used the human lung epithelial cell line A549 as a model to investigate the changes in RNA expression after 24 hours of infection with H13N2 virus. These findings provide important insights into the cross-species transmission mechanism of H13N2 virus and its impact on host cells, while also offering a scientific basis for assessing its potential public health risks and developing prevention strategies.
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Direct links to NCBI, no account and no request form: the whole study as GSE309539_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1336222 and SRA study SRP629613. Searching any of these in the dataset finder brings you back here.

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