Disease-associated mutations on the STAT5B SH2 domain regulate cholesterol and lipid metabolism in liver
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 85 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 85 samples: 24 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolismbioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310018_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1364991 and SRA study SRP644779. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 85 samples.
How we read this: 24 replicated groups read from 85 sample titles; they account for 85 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9285191 WT_STAT5B_rep1 WT_STAT5B
- GSM9285192 WT_STAT5B_rep2 WT_STAT5B
- GSM9285193 WT_H3K27ac_rep1 WT_H3K27ac
- GSM9285194 WT_H3K27ac_rep2 WT_H3K27ac
- GSM9285195 WT_PolII_rep1 WT_PolII
- GSM9285196 WT_PolII_rep2 WT_PolII
- GSM9285197 Y665F_STAT5B_rep1 Y665F_STAT5B
- GSM9285198 Y665F_STAT5B_rep2 Y665F_STAT5B
- GSM9285199 Y665F_H3K27ac_rep1 Y665F_H3K27ac
- GSM9285200 Y665F_H3K27ac_rep2 Y665F_H3K27ac
- GSM9285201 Y665F_PolII_rep1 Y665F_PolII
- GSM9285202 Y665F_PolII_rep2 Y665F_PolII
- GSM9285203 Y665H_STAT5B_rep1 Y665H_STAT5B
- GSM9285204 Y665H_STAT5B_rep2 Y665H_STAT5B
- GSM9285205 Y665H_H3K27ac_rep1 Y665H_H3K27ac
- GSM9285206 Y665H_H3K27ac_rep2 Y665H_H3K27ac
- GSM9285207 Y665H_PolII_rep1 Y665H_PolII
- GSM9285208 Y665H_PolII_rep2 Y665H_PolII
- GSM9285209 Y665F_female_STAT5B_rep1 Y665F_female_STAT5B
- GSM9285210 Y665F_female_STAT5B_rep2 Y665F_female_STAT5B
- GSM9285211 Y665F_female_H3K27ac_rep1 Y665F_female_H3K27ac
- GSM9285212 Y665F_female_H3K27ac_rep2 Y665F_female_H3K27ac
- GSM9285213 Y665F_female_PolII_rep1 Y665F_female_PolII
- GSM9285214 Y665F_female_PolII_rep2 Y665F_female_PolII
- GSM9285215 WT_male_rep1 WT_male
- GSM9285216 WT_male_rep2 WT_male
- GSM9285217 WT_male_rep3 WT_male
- GSM9285218 WT_male_rep4 WT_male
- GSM9285219 Y665F_male_rep1 Y665F_male
- GSM9285220 Y665F_male_rep2 Y665F_male
- GSM9285221 Y665F_male_rep3 Y665F_male
- GSM9285222 Y665F_male_rep4 Y665F_male
- GSM9285223 Y665H_male_rep1 Y665H_male
- GSM9285224 Y665H_male_rep2 Y665H_male
- GSM9285225 Y665H_male_rep3 Y665H_male
- GSM9285226 Y665H_male_rep4 Y665H_male
- GSM9285227 WT_female_rep1 WT_female
- GSM9285228 WT_female_rep2 WT_female
- GSM9285229 WT_female_rep3 WT_female
- GSM9285230 WT_female_rep4 WT_female
+ 45 more — browse all 85 samples with per-sample file links →
- GSE310017 Disease-associated mutations on the STAT5B SH2 domain regulate cholesterol and lipid metabolism in liver [RNA-Seq liver] 37 samples shares stat5b, sh2, disease-associated, cholesterol, mutations, regulate, domain, lipid
- GSE270652 Human mutations, altering a single tyrosine in the STAT5B SH2 domain, have opposing impacts on enhancer function and mammary development 65 samples shares stat5b, sh2, mutations, domain
- GSE276311 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [RNA-seq] 61 samples shares stat5b, sh2, mutations, domain
- GSE276312 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [scRNA-seq] 23 samples shares stat5b, sh2, mutations, domain
- GSE270656 Human mutations, altering a single tyrosine in the STAT5B SH2 domain, have opposing impacts on enhancer function and mammary development [RNA-seq] 18 samples shares stat5b, sh2, mutations, domain
- GSE276308 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [ChIP-seq] 13 samples shares stat5b, sh2, mutations, domain
- GSE338662 STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs 18 samples shares sh2, mutations, domain
- GSE290401 Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune tolerance 60 samples shares sh2, regulate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.