A Neutrophil–Mesangial Cell Axis Promotes Glomerular Injury in Lupus Nephritis
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A neutrophil-mesangial cell axis promotes glomerular injury in lupus nephritisAnnals of the rheumatic diseases · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310054_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1365062 and SRA study SRP644964. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9287360 Human mesangial cells, control 1, 72hr
- GSM9287361 Human mesangial cells, control 2, 72hr
- GSM9287362 Human mesangial cells, control 3, 72hr
- GSM9287363 Human mesangial cells, control 4, 72hr
- GSM9287364 Human mesangial cells, control 5, 72hr
- GSM9287365 Human mesangial cells, NETs 1, 72hr
- GSM9287366 Human mesangial cells, NETs 2, 72hr
- GSM9287367 Human mesangial cells, NETs 3, 72hr
- GSM9287368 Human mesangial cells, NETs 4, 72hr
- GSM9287369 Human mesangial cells, NETs 5, 72hr
- GSM9287370 Human mesangial cells, control 1, 48hr
- GSM9287371 Human mesangial cells, control 2, 48hr
- GSM9287372 Human mesangial cells, control 3, 48hr
- GSM9287373 Human mesangial cells, control 4, 48hr
- GSM9287374 Human mesangial cells, control 5, 48hr
- GSM9287375 Human mesangial cells, CitH3 1, 48hr
- GSM9287376 Human mesangial cells, CitH3 2, 48hr
- GSM9287377 Human mesangial cells, CitH3 3, 48hr
- GSM9287378 Human mesangial cells, CitH3 4, 48hr
- GSM9287379 Human mesangial cells, CitH3 5, 48hr
- GSE296560 Lupus nephritis serum induces changes in gene expression in human glomerular endothelial cells, which is modulated by L-sepiapterin: Implications for redox-mediated endothelial dysfunction 19 samples shares glomerular, nephritis, lupus
- GSE271120 TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers [MDA-MB-231] 17 samples shares neutrophil, promotes, axis
- GSE302316 Neutrophil transcriptomes in blunt traumatic injury 80 samples shares neutrophil, injury
- GSE293224 RNAseq analysis of human neutrophils from healthy controls and from people with systemic lupus eruthematosus 35 samples shares neutrophil, lupus
- GSE261866 Lupus neutrophils transcriptome 27 samples shares neutrophil, lupus
- GSE322527 Single-cell transcriptomes and T cell receptor sequences of CD4 or CD8 single positive T lymphocytes from peripheral blood or urine of lupus nephritis patients at flare. 26 samples shares nephritis, lupus
- GSE232381 RNA-seq of Peripheral Blood Cells Identifies Molecular Network Linked to Lymphocyte Subset Aberrations and Active Lupus Nephritis in SLE 25 samples shares nephritis, lupus
- GSE239576 Comparison of Renal Transcriptome Profiles in Patients with Active Lupus Nephritis Reveals Possible New Mechanisms of Disease Progression 21 samples shares nephritis, lupus
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.