GEO series
A Neutrophil–Mesangial Cell Axis Promotes Glomerular Injury in Lupus Nephritis
GSE310054
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2026/03/10
GPL34284
Summary
Neutrophil extracellular trap (NET)-producing neutrophils infiltrate the kidney early in lupus nephritis (LN). NET-derived citrullinated histone H3 activates mesangial cells (MCs) through TLR4, promoting inflammation and fibrosis, establishing a novel NET–MC axis that may represent a mechanistic driver and therapeutic target in LN.
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Paper (PMID 41354562) ↗
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