GEO series

Retinoic acid regulates macular development in the human retina

GSE310245 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/10 Platform GPL24676Platform GPL18573

Summary

The human retina possesses a region, the macula, specialized for high acuity vision, with a high density of cones and no rod photoreceptors. The mechanisms involved in macular formation are poorly understood. Increasing evidence suggests that retinoic acid (RA) may play a key role in its development. Specifically low RA levels in the macula, maintained by CYP26A1, leads to early cell cycle exit for macular progenitors, and a low rod to cone ratio. To test this model, we performed single cell RNA sequencing on Fetal D57 retina to examine the distribution of RA-associated genes across the central and peripheral retina.

Published in

Retinoic acid regulates foveal development in the human retina

Wohlschlegel J, Kaplan L, Lee LR et al. · Cell reports 2026 · PMID 42213783 · doi:10.1016/j.celrep.2026.117379

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Direct links to NCBI, no account and no request form: the whole study as GSE310245_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1365526 and SRA study SRP645784. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42213783) ↗

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