Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 33 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 33 samples: 33 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Modulating AP-1 enables CAR T cells to establish an intratumoral stemlike reservoir and overcomes resistance to PD-1 blockadeScience immunology · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310251_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1365518 and SRA study SRP645828. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 33 sample titles: 33 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9292459 1_IP_78_rep1
- GSM9292460 2_IP_78_rep2
- GSM9292461 3_IP_78_rep3
- GSM9292462 4_IP_95_rep1
- GSM9292463 5_IP_95_rep2
- GSM9292464 6_IP_95_rep3
- GSM9292465 7_IP_SN10_rep1
- GSM9292466 8_IP_SN10_rep2
- GSM9292467 9_IP_SN10_rep3
- GSM9292468 10_D8_78_2
- GSM9292469 11_D8_78_4
- GSM9292470 12_D8_78_5
- GSM9292471 13_D8_95_6
- GSM9292472 14_D8_95_10
- GSM9292473 15_D8_95_11
- GSM9292474 16_D8_SN10_14
- GSM9292475 17_D8_SN10_16
- GSM9292476 18_D8_SN10_17
- GSM9292477 1_IP_SS95_rep1_IgG
- GSM9292478 2_IP_SS95_rep2_IgG
- GSM9292479 3_IP_SN10_rep1_IgG
- GSM9292480 4_IP_SN10_rep2_IgG
- GSM9292481 9_IP_SS78_rep1_H3K4me3
- GSM9292482 10_IP_SS78_rep2_H3K4me3
- GSM9292483 11_IP_SS95_rep1_H3K4me3
- GSM9292484 12_IP_SS95_rep2_H3K4me3
- GSM9292485 13_IP_SN10_rep1_H3K4me3
- GSM9292486 14_IP_SN10_rep2_H3K4me3
- GSM9292487 21_IP_SS78_rep1_H3K27me3
- GSM9292488 22_IP_SS78_rep2_H3K27me3
- GSM9292489 23_IP_SS95_rep1_H3K27me3
- GSM9292490 24_IP_SS95_rep2_H3K27me3
- GSM9292491 25_IP_SN10_rep1_H3K27me3
- GSE310249 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 18 samples shares car-t, ap-1, pd-1, intratumoral, modulating, resistance, establish, stem-like
- GSE310740 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 16 samples shares car-t, ap-1, pd-1, intratumoral, modulating, resistance, establish, stem-like
- GSE310250 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 15 samples shares car-t, ap-1, pd-1, intratumoral, modulating, resistance, establish, stem-like
- GSE288687 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 12 samples shares car-t, ap-1, pd-1, intratumoral, modulating, resistance, establish, stem-like
- GSE293295 Discovery of BMS-986408, a First-In-Class Dual DGK⍺ and DGK Inhibitor That Unleashes PD-1 Checkpoint and CAR-T Cell Immunotherapies 20 samples shares car-t, pd-1
- GSE273488 Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans (RNA-Seq II). 42 samples shares pd-1, establish
- GSE285965 Mannose enhances anti-PD-1 therapy efficacy in ovarian cancer via modulating gut microbial metabolite [Peritoneum] 24 samples shares pd-1, modulating
- GSE261642 PLPP1-deficiency-mediated ferroptosis induced by PD-1 signaling impairs antitumor activity of intratumoral CD8+ T cells I 23 samples shares pd-1, intratumoral
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.