GEO series
Gene expression profiles of intestinal organoids under collagen/Matrigel culture and 5-fluorouracil treatment in human
GSE310408
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/01/09
GPL34284
Summary
In this study, we examined how 5-fluorouracil (5-FU) treatment modulates transcriptional programs in human intestinal organoids cultured in Matrigel or collagen matrices. By comparing Matrigel-embedded and collagen-embedded organoids under control and 5-FU–treated conditions, we identified ECM-dependent and treatment-specific gene expression changes associated with cellular stress responses, epithelial regeneration, and matrix-driven phenotypic differences.
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Paper (PMID 41530496) ↗
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