Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate Cancer
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Prostate cancerThis series is part of our curated briefing on it.
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate CancerbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310499_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1366442 and SRA study SRP647831. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9302227 C4-2 cells, 7 mM glucose, biological replicate 1 C4-2 cells, 7 mM glucos…
- GSM9302229 C4-2 cells, 7 mM glucose, biological replicate 2 C4-2 cells, 7 mM glucos…
- GSM9302231 C4-2 cells, 7 mM glucose, biological replicate 3 C4-2 cells, 7 mM glucos…
- GSM9302233 MDA-Pca-2b cells, 7 mM glucose, biological replicate 1 MDA-Pca-2b cells, 7 mM …
- GSM9302235 MDA-Pca-2b cells, 7 mM glucose, biological replicate 2 MDA-Pca-2b cells, 7 mM …
- GSM9302237 MDA-Pca-2b cells, 7 mM glucose, biological replicate 3 MDA-Pca-2b cells, 7 mM …
- GSM9302239 C4-2 cells, 25 mM glucose, biological replicate 1 C4-2 cells, 25 mM gluco…
- GSM9302242 C4-2 cells, 25 mM glucose, biological replicate 2 C4-2 cells, 25 mM gluco…
- GSM9302244 C4-2 cells, 25 mM glucose, biological replicate 3 C4-2 cells, 25 mM gluco…
- GSM9302246 MDA-Pca-2b cells, 25 mM glucose, biological replicate 1 MDA-Pca-2b cells, 25 mM…
- GSM9302248 MDA-Pca-2b cells, 25 mM glucose, biological replicate 2 MDA-Pca-2b cells, 25 mM…
- GSM9302251 MDA-Pca-2b cells, 25 mM glucose, biological replicate 3 MDA-Pca-2b cells, 25 mM…
- GSM9302253 C4-2 cells, 500 µM methylglyoxal, biological replicate 1 C4-2 cells, 500 µM meth…
- GSM9302255 C4-2 cells, 500 µM methylglyoxal, biological replicate 2 C4-2 cells, 500 µM meth…
- GSM9302257 C4-2 cells, 500 µM methylglyoxal, biological replicate 3 C4-2 cells, 500 µM meth…
- GSM9302259 MDA-Pca-2b cells, 500 µM methylglyoxal, biological replicate 1 MDA-Pca-2b cells, 500 µ…
- GSM9302260 MDA-Pca-2b cells, 500 µM methylglyoxal, biological replicate 2 MDA-Pca-2b cells, 500 µ…
- GSM9302261 MDA-Pca-2b cells, 500 µM methylglyoxal, biological replicate 3 MDA-Pca-2b cells, 500 µ…
- GSE115501 RNA sequencing on circulating tumor cells from prostate cancer patients 136 samples same disease briefing · shares prostate
- GSE222467 The RNA binding proteins LARP4A and LARP4B promote tumour growth and metastasis in prostate cancer and osteosarcoma 12 samples same disease briefing · shares prostate
- GSE300947 A novel six-biomarker panel identified from male breast cancer-associated fibroblasts demonstrates prognostic power for prostate tumors 6 samples same disease briefing · shares prostate
- GSE120181 Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment 2 samples same disease briefing · shares prostate
- GSE242541 ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity 12 samples same disease briefing
- GSE71008 Plasma extracellular RNA profiles in healthy and cancer patients 192 samples same disease briefing
- GSE319878 Interrogating the mechanistic link between neighborhood deprivation and colorectal cancer risk through gene expression analysis of normal colorectal biopsies 171 samples shares mechanistic, link
- GSE279872 Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output in Prostate Cancer [RNA-seq] 30 samples shares oncogenic, prostate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.