GEO series
Whole transcriptomics data under different extracellular matrix stiffness in NB cells
GSE310716
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/11/21
GPL29480
Summary
Nuclear pore complex (NPC), the gatekeepers of macromolecules across the nuclear envelope (NE), undergoes dynamic changes pivotal in physiology and pathology. Our study established ECM stiffness as a key driver of NB cell migration through a novel lamin A/C/E2F4/PLK1 axis, which governed post-mitotic NPC assembly and nucleocytoplasmic transport function. Targeting NPC-mediated transport may represent a promising therapeutic strategy for NB.
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