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IKAROS re-expression modulates transcriptional networks in IKZF1-mutant Ph+ B-ALL [HiChIP]

GSE310891 Homo sapiens Other 4 samples Submitted 2026/02/20 Platform GPL24676
Summary
With the goal to investigate tumor suppressor mechanisms regulated by IKAROS (IKZF1) in PH chromosome–positive B-cell acute lymphoblastic leukemia (B-ALL) harboring IKZF1 mutations. This dataset includes bulk RNA-seq profiles from human MXP5 and PDX2 cell lines, which were engineered to express doxycycline-inducible wild-type IKAROS (IK1) or an empty vector control. RNA was collected 24 hours post-induction to capture early transcriptional responses to IK1 re-expression. These data are part of a larger multi-omics study integrating RNA-seq, ChIP-seq, CUT&RUN, ATAC-seq, and HiChIP to define IKAROS-regulated transcriptional and chromatin networks in IKZF1-deficient Ph⁺ B-ALL.
Published in
IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia
Paculova H, Richman A, Boyd J et al. · bioRxiv : the preprint server for biology 2025 · PMID 41509392 · doi:10.64898/2025.12.29.696402
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Also filed as BioProject PRJNA1367491. Searching any of these in the dataset finder brings you back here.

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