GEO series
Sensitive CAR T cells redefine targetable CD70 expression in solid tumors [ATAC-seq]
GSE311096
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
37 samples
2026/02/26
GPL24676
Summary
CD70 expression in solid tumors is heterogeneous. We demonstrate that cells appearing CD70-negative retain ultra-low levels of CD70 expression. These cells that appear negative by conventional detection methods. Bulk ATAC-seq analysis of FACS-sorted CD70⁻ and CD70⁺ tumor populations revealed differential chromatin accessibility, indicating epigenetic regulation of CD70 expression in both ccRCC and HGSOC models.
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Paper (PMID 41747043) ↗
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